When cocaine and alcohol meet inside a person, they create a third unique drug called cocaethylene. Cocaethylene works like cocaine, but with more euphoria.
So in 1863, when Parisian chemist Angelo Mariani combined coca and wine and started selling it, a butterfly did flap its wings. His Vin Marian became extremely popular. Jules Verne, Alexander Dumas, and Arthur Conan Doyle were among literary figures said to have used it, and the chief rabbi of France said, "Praise be to Mariani's wine!"
Pope Leo XIII reportedly carried a flask of it regularly and gave Mariani a medal.
Seeing this commercial success, Dr. John Stith Pemberton in Atlanta—himself a morphine addict following an injury in the Civil War—set out to make his own version. He called it Pemberton's French Wine Coca and marketed it as a panacea. Among many fantastic claims, he called it "a most wonderful invigorator of sexual organs."
But as Pemberton's business started to take off, a prohibition was passed in his county in Georgia (a local one that predated the 18th Amendment by 34 years). Soon French Wine Coca was illegal—because of the alcohol, not the cocaine.
Pemberton remained a step ahead, though. He replaced the wine in the formula with (healthier?) sugar syrup. His new product debuted in 1886: "Coca-Cola: The temperance drink."
After that, as Grace Elizabeth Hale recounted recently in the The New York Times, Coca-Cola "quickly caught on as an 'intellectual beverage' among well-off whites." But when the company started selling it in bottles in 1899, minorities who couldn't get into the segregated soda fountains suddenly had access to it.
Hale explains:
Anyone with a nickel, black or white, could now drink the cocaine-infused beverage. Middle-class whites worried that soft drinks were contributing to what they saw as exploding cocaine use among African-Americans. Southern newspapers reported that "negro cocaine fiends" were raping white women, the police powerless to stop them. By 1903, [then-manager of Coca-Cola Asa Griggs] Candler had bowed to white fears (and a wave of anti-narcotics legislation), removing the cocaine and adding more sugar and caffeine.
Hale's account of the role of racism and social injustice in Coca-Cola's removal of coca is corroborated by the attitudes that the shaped subsequent U.S. cocaine regulation movement. Cocaine wasn't even illegal until 1914—11 years after Coca-Cola's change—but a massive surge in cocaine use was at its peak at the turn of the century. Recreational use increased five-fold in a period of less than two decades. During that time, racially oriented arguments about rape and other violence, and social effects more so than physical health concerns, came to shape the discussion.
The same hypersexuality that was touted as a selling point during the short-lived glory days of Vin Mariani was now a crux of cocaine's bigoted indictment. U.S. State Department official Dr. Hamilton Wright said in 1910, "The use of cocaine by the negroes of the South is one of the most elusive and troublesome questions which confront the enforcement of the law ... often the direct incentive to the crime of rape by the negroes." Dr. Edward Williams described in the Medical Standard in 1914, "The negro who has become a cocaine-doper is a constant menace to his community. His whole nature is changed for the worse ... timid negroes develop a degree of 'Dutch courage' which is sometimes almost incredible."
Yes, even the Dutch were not spared from the racism.
The Coca-Cola we know today still contains coca—but the ecgonine alkaloid (which forms cocaine) is removed from it. Perfecting that extraction took until 1929, so before that there were still trace amounts of coca's psychoactive elements in Coca-Cola. As Dominic Streatfield describes in Cocaine: An Unauthorized Biography, the extraction is now done in a New Jersey warehouse by a company called Stepan Chemicals. As of 2003, Stepan imported 175,000 kilograms of coca for Coca-Cola every year -- which they refer to simply as "Merchandise Number 5." That's enough to make more than $200 million worth of cocaine.
The warehouse is guarded.